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The antibody against RFX6 was raised in rabbit using the Recombinant Human DNA-binding protein RFX6 protein (1-260AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against RFX6 was raised in rabbit using the Recombinant Human DNA-binding protein RFX6 protein (1-260AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human pancreatic tissue using RFX6 Antibody at dilution of 1:100
| Cat.No | ADC-22499A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RFX6 |
| Target Synonyms | RFX6 antibody; RFXDC1 antibody; DNA-binding protein RFX6 antibody; Regulatory factor X 6 antibody; Regulatory factor X domain-containing protein 1 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human DNA-binding protein RFX6 protein (1-260AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8HWS3 |
Uniprot Id
Q8HWS3
Target Species
Human
Target Name
RFX6
Target Full Name
DNA-binding protein RFX6
Target Function
Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin. Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes. Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription.
Target Involvement
Mitchell-Riley syndrome (MTCHRS)
Target Subcellular Location
Nucleus.
Target Protein Families
RFX family
Target Tissue Specificity
Expressed in pancreas. Expressed in pancreatic beta-cells (insulin-positive cells) and alpha-cells (glucagon-positive cells) (at protein level). Specifically expressed in pancreas, small intestine and colon. Expressed in endocrine cells in the islets.
Target Synonyms
RFX6; RFXDC1; DNA-binding protein RFX6; Regulatory factor X 6; Regulatory factor X domain-containing protein 1
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