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The antibody against RNF182 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase RNF182 protein (1-160AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against RNF182 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase RNF182 protein (1-160AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunofluorescent analysis of A431 cells using RNF182 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Immunohistochemistry of paraffin-embedded human tonsil tissue using RNF182 Antibody at dilution of 1:1002
Immunohistochemistry of paraffin-embedded human liver cancer using RNF182 Antibody at dilution of 1:1003
| Cat.No | ADC-23806A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RNF182 |
| Target Synonyms | RNF182; E3 ubiquitin-protein ligase RNF182; RING finger protein 182; RING-type E3 ubiquitin transferase RNF182 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase RNF182 protein (1-160AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N6D2 |
Uniprot Id
Q8N6D2
Target Species
Human
Target Name
RNF182
Target Full Name
E3 ubiquitin-protein ligase RNF182
Target Function
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Plays also a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA.
Target Subcellular Location
Membrane; Multi-pass membrane protein. Cytoplasm.
Target Tissue Specificity
Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains. Highly expressed in innate immune organs such as lymph nodes and spleen
Target Research Area
Cell Biology
Target Synonyms
RNF182; E3 ubiquitin-protein ligase RNF182; RING finger protein 182; RING-type E3 ubiquitin transferase RNF182
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