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The antibody against RNF26 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase RNF26 protein (246-433AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
The antibody against RNF26 was raised in rabbit using the Recombinant Human E3 ubiquitin-protein ligase RNF26 protein (246-433AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC, IF.
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Immunohistochemistry of paraffin-embedded human colon cancer using RNF26 Antibody at dilution of 1:1002
| Cat.No | ADC-23798A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | RNF26 |
| Target Synonyms | RNF26; E3 ubiquitin-protein ligase RNF26; RING finger protein 26 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human E3 ubiquitin-protein ligase RNF26 protein (246-433AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BY78 |
Uniprot Id
Q9BY78
Target Species
Human
Target Name
RNF26
Target Full Name
E3 ubiquitin-protein ligase RNF26
Target Function
E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1. Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport. Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING. Also required to limit type I interferon response by promoting autophagic degradation of IRF3.
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Target Tissue Specificity
Ubiquitous. Up-regulated in several cancer cell lines.
Target Synonyms
RNF26; E3 ubiquitin-protein ligase RNF26; RING finger protein 26
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