Rabbit anti-Human ROR2 Polyclonal Antibody

Uniprot Id

Q01974

Target Species

Human

Target Name

ROR2

Target Full Name

Tyrosine-protein kinase transmembrane receptor ROR2

Target Function

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.

Target Involvement

Brachydactyly B1 (BDB1); Robinow syndrome autosomal recessive (RRS)

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Target Protein Families

Protein kinase superfamily, Tyr protein kinase family, ROR subfamily

Target Synonyms

BDB; BDB1; NTRKR2; ROR2

Target Background

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.