Rabbit anti-Human RPS19 Polyclonal Antibody

Uniprot Id

P39019

Target Species

Human

Target Name

RPS19

Target Full Name

Small ribosomal subunit protein eS19

Target Function

Required for pre-rRNA processing and maturation of 40S ribosomal subunits.

Target Involvement

Diamond-Blackfan anemia 1 (DBA1)

Target Subcellular Location

Nucleus. Note=Located more specifically in the nucleoli.

Target Protein Families

Eukaryotic ribosomal protein eS19 family

Target Tissue Specificity

Higher level expression is seen in the colon carcinoma tissue than normal colon tissue.

Target Synonyms

40S ribosomal protein S19; DBA; DBA1; HGNC:10402; Ribosomal protein S19; rps19; RS19_HUMAN; S19

Target Background

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.