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The antibody against SBF2 was raised in rabbit using the Recombinant Human Myotubularin-related protein 13 protein (1585-1813AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against SBF2 was raised in rabbit using the Recombinant Human Myotubularin-related protein 13 protein (1585-1813AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-15281A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SBF2 |
| Target Synonyms | SBF2 antibody; CMT4B2 antibody; KIAA1766 antibody; MTMR13 antibody; Myotubularin-related protein 13 antibody; Inactive phosphatidylinositol 3-phosphatase 13 antibody; SET-binding factor 2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | HRP conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Myotubularin-related protein 13 protein (1585-1813AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q86WG5 |
Uniprot Id
Q86WG5
Target Species
Human
Target Name
SBF2
Target Full Name
Myotubularin-related protein 13
Target Function
Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Acts as an adapter for the phosphatase MTMR2. Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate.
Target Involvement
Charcot-Marie-Tooth disease 4B2 (CMT4B2)
Target Subcellular Location
Cytoplasm. Cytoplasm, perinuclear region. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Cell projection, axon.
Target Protein Families
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Target Tissue Specificity
Widely expressed. Expressed in spinal cord.
Target Synonyms
SBF2; CMT4B2; KIAA1766; MTMR13; Myotubularin-related protein 13; Inactive phosphatidylinositol 3-phosphatase 13; SET-binding factor 2
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