Rabbit anti-Human SCN10A Polyclonal Antibody

Uniprot Id

Q9Y5Y9

Target Species

Human

Target Name

SCN10A

Target Full Name

Sodium channel protein type 10 subunit alpha

Target Function

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.

Target Involvement

Episodic pain syndrome, familial, 2 (FEPS2)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Sodium channel (TC 1.A.1.10) family, Nav1.8/SCN10A subfamily

Target Tissue Specificity

Expressed in the dorsal root ganglia and sciatic nerve.

Target Synonyms

PN3; SNS; FEPS2; Nav1.8; SCN10A

Target Background

The protein encoded by this gene is a tetrodotoxin-resistant voltage-gated sodium channel alpha subunit. The properties of the channel formed by the encoded transmembrane protein can be altered by interaction with different beta subunits. This protein may be involved in the onset of pain associated with peripheral neuropathy. Alternative splicing results in multiple transcript variants.