Rabbit anti-Human SCN11A Polyclonal Antibody

Uniprot Id

Q9UI33

Target Species

Human

Target Name

SCN11A

Target Full Name

Sodium channel protein type 11 subunit alpha

Target Function

This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.

Target Involvement

Neuropathy, hereditary sensory and autonomic, 7 (HSAN7); Episodic pain syndrome, familial, 3 (FEPS3)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

Sodium channel (TC 1.A.1.10) family, Nav1.9/SCN11A subfamily

Target Tissue Specificity

Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.

Target Synonyms

hNaN; NaN; NAV1.9; Peripheral nerve sodium channel 5; PN 5; PN5; SCN 11A; SCN 12A; Scn11a; SCN12A; SCNBA_HUMAN; Sensory neuron sodium channel 2; SNS 2; SNS2; Sodium channel protein type 11 subunit alpha; Sodium channel protein type XI subunit alpha; Sodium channel voltage gated type XI alpha; Sodium channel voltage gated type XI alpha polypeptide; Sodium channel voltage gated type XI alpha subunit; Sodium channel voltage gated type XII alpha polypeptide; Voltage gated sodium channel Nav1.9; Voltage gated sodium channel subunit alpha Nav1.9; Voltage-gated sodium channel subunit alpha Nav1.9