Rabbit anti-Human SCNN1B Polyclonal Antibody, Biotin conjugated

Uniprot Id

P51168

Target Species

Human

Target Name

SCNN1B

Target Full Name

Epithelial sodium channel subunit beta

Target Function

Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.

Target Involvement

Pseudohypoaldosteronism 1, autosomal recessive (PHA1B); Liddle syndrome (LIDLS); Bronchiectasis with or without elevated sweat chloride 1 (BESC1)

Target Subcellular Location

Apical cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane.

Target Protein Families

Amiloride-sensitive sodium channel (TC 1.A.6) family, SCNN1B subfamily

Target Tissue Specificity

Detected in placenta, lung and kidney. Expressed in kidney (at protein level).

Target Synonyms

Amiloride sensitive sodium channel subunit beta; Amiloride-sensitive sodium channel subunit beta; Beta NaCH; Beta-ENaC; Beta-NaCH; ENaC beta; ENaCB; Epithelial Na(+) channel subunit beta; Epithelial Na+ channel beta subunit; Epithelial Na+ channel subunit beta; Epithelial sodium channel beta 2 subunit; Epithelial sodium channel beta 3 subunit; Nonvoltage gated sodium channel 1 beta subunit; Nonvoltage gated sodium channel 1 subunit beta; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB; SCNN 1B; SCNN1B; SCNNB_HUMAN; Sodium channel nonvoltage gated 1 beta (Liddle syndrome); Sodium channel nonvoltage gated 1 beta

Target Background

Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.