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The antibody against SGO2 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Sgo2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
The antibody against SGO2 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human Sgo2. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, ELISA.
$167.00
| Cat.No | ADC-36220A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SGO2 |
| Target Synonyms | Sgo2 antibody; Sgol2 antibody; SGOL2_HUMAN antibody; Shugoshin-2 antibody; Shugoshin-like 2 antibody; Tripin antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human Sgo2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q562F6 |
Uniprot Id
Q562F6
Target Species
Human
Target Name
SGO2
Target Full Name
Shugoshin 2
Target Function
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase.
Target Subcellular Location
Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.
Target Protein Families
Shugoshin family
Target Synonyms
Sgo2; Sgol2; SGOL2_HUMAN; Shugoshin-2; Shugoshin-like 2; Tripin
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