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The antibody against SH2D1B was raised in rabbit using the Recombinant Human SH2 domain-containing protein 1B protein (1-77AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against SH2D1B was raised in rabbit using the Recombinant Human SH2 domain-containing protein 1B protein (1-77AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human colon cancer using SH2D1B Antibody at dilution of 1:100
Immunofluorescent analysis of HepG2 cells using SH2D1B Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)2
| Cat.No | ADC-14566A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SH2D1B |
| Target Synonyms | SH2D1B antibody; EAT2 antibody; SH2 domain-containing protein 1B antibody; EWS/FLI1-activated transcript 2 antibody; EAT-2 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human SH2 domain-containing protein 1B protein (1-77AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O14796 |
Uniprot Id
O14796
Target Species
Human
Target Name
SH2D1B
Target Full Name
SH2 domain-containing protein 1B
Target Function
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244. In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation. Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling. In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse. Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation.
Target Synonyms
SH2D1B; EAT2; SH2 domain-containing protein 1B; EWS/FLI1-activated transcript 2; EAT-2
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