Rabbit anti-Human SH3GL1 Polyclonal Antibody

Uniprot Id

Q99961

Target Species

Human

Target Name

SH3GL1

Target Full Name

Endophilin-A2

Target Function

Implicated in endocytosis. May recruit other proteins to membranes with high curvature.

Target Involvement

In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene.

Target Subcellular Location

Cytoplasm. Early endosome membrane; Peripheral membrane protein. Cell projection, podosome.

Target Protein Families

Endophilin family

Target Tissue Specificity

Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus.

Target Research Area

Cell Biology

Target Synonyms

CNSA1; EEN; EEN fusion partner of MLL; Endophilin-2; Endophilin-A2; Extra 11 19 leukemia fusion gene; Extra eleven-nineteen leukemia fusion gene protein; Fusion partner of MLL; MGC111371; SH3 containing Grb 2 like 1 protein; SH3 containing protein EEN; SH3 domain GRB2 like 1; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3D2B; SH3G1_HUMAN; Sh3gl1; SH3P8

Target Background

This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.