Rabbit anti-Human SLC12A6 Polyclonal Antibody

Uniprot Id

Q9UHW9

Target Species

Human

Target Name

SLC12A6

Target Full Name

Solute carrier family 12 member 6

Target Function

Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells.

Target Involvement

Agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)

Target Subcellular Location

Basolateral cell membrane; Multi-pass membrane protein.

Target Protein Families

SLC12A transporter family

Target Tissue Specificity

Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proxi

Target Synonyms

ACCPN; Electroneutral potassium-chloride cotransporter 3; Furosemide sensitive KCl cotransporter 3; Gaxp; K-Cl cotransporter 3; KCC 3; KCC 3A; KCC 3B; KCC3 A; KCC3; KCC3 B; KCC3A; KCC3B; Potassium chloride cotransporter 3; Potassium chloride cotransporter KCC3a S3; S12A6_HUMAN; SLC12 A6; SLC12A 6; SLC12A6; Solute carrier family 12 (potassium/chloride transporters); member 6; Solute carrier family 12 member 6; Solute carrier family 12; member 6

Target Background

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.