Rabbit anti-Human SLC1A1 Polyclonal Antibody

Uniprot Id

P43005

Target Species

Human

Target Name

SLC1A1

Target Full Name

Excitatory amino acid transporter 3

Target Function

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Can also transport L-cysteine. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport. Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli. Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate. Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport. Negatively regulated by ARL6IP5.

Target Involvement

Dicarboxylic aminoaciduria (DCBXA); Schizophrenia 18 (SCZD18)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome. Early endosome membrane. Late endosome membrane. Recycling endosome membrane.

Target Protein Families

Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family, SLC1A1 subfamily

Target Tissue Specificity

Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).

Target Research Area

Neuroscience

Target Synonyms

EAA3_HUMAN; EAAC 1; EAAC1; EAAT 3; Excitatory amino acid carrier 1 ; Excitatory amino acid carrier1; Excitatory amino acid transporter 3; Excitatory amino acid transporter3; Excitatory amino-acid carrier 1; GLUTAMATE TRANSPORTER; HIGH-AFFINITY; MEAAC 1; MEAAC1; Neuronal and epithelial glutamate transporter; REAAC 1; REAAC1; Slc1 a1; Slc1a 1; SLC1A1; Sodium dependent glutamate/aspartate transporter 3; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 (neuronal / epithelial high affinity glutamate transporter; system Xag); member 1; SOLUTE CARRIER FAMILY 1 (NEURONAL/EPITHELIAL HIGH AFFINITY GLUTAMATE TRANSPORTER); MEMBER 1; Solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter; system Xag); member 1; Solute carrier family 1 member 1; Solute carrier family 1; member 1

Target Background

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.