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The antibody against SLC25A12 was raised in rabbit using the Synthesized peptide derived from internal of Human CMC1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, IHC.
The antibody against SLC25A12 was raised in rabbit using the Synthesized peptide derived from internal of Human CMC1. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue using CMC1 antibody.
| Cat.No | ADC-41044A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SLC25A12 |
| Target Synonyms | SLC25A12; ARALAR1; Calcium-binding mitochondrial carrier protein Aralar1; Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12 | Form | Liquid |
| Species Reactivity | Human, Mouse | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human CMC1. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O75746 |
Uniprot Id
O75746
Target Species
Human
Target Name
SLC25A12
Target Full Name
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial
Target Function
Mitochondrial and calcium-binding carrier that catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.
Target Involvement
Epileptic encephalopathy, early infantile, 39 (EIEE39)
Target Subcellular Location
Mitochondrion inner membrane; Multi-pass membrane protein.
Target Protein Families
Mitochondrial carrier (TC 2.A.29) family
Target Tissue Specificity
Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney.
Target Synonyms
SLC25A12; ARALAR1; Calcium-binding mitochondrial carrier protein Aralar1; Mitochondrial aspartate glutamate carrier 1; Solute carrier family 25 member 12
Target Background
This gene encodes a calcium-binding mitochondrial carrier protein. The encoded protein localizes to the mitochondria and is involved in the exchange of aspartate for glutamate across the inner mitochondrial membrane. Polymorphisms in this gene may be associated with autism, and mutations in this gene may also be a cause of global cerebral hypomyelination. Alternatively spliced transcript variants have been observed for this gene.
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