Rabbit anti-Human SLC9A6 Polyclonal Antibody

Uniprot Id

Q92581

Target Species

Human

Target Name

SLC9A6

Target Full Name

Sodium/hydrogen exchanger 6

Target Function

Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.

Target Involvement

Mental retardation, X-linked, syndromic, Christianson type (MRXSCH)

Target Subcellular Location

Endosome membrane; Multi-pass membrane protein. Note=Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane.; [Isoform 2]: Recycling endosome membrane; Multi-pass membrane protein.

Target Protein Families

Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

Target Tissue Specificity

Ubiquitous; but is most abundant in mitochondrion-rich tissues such as brain, skeletal muscle and heart.

Target Synonyms

3732426M05; 6430520C02Rik; KIAA0267; mKIAA0267; MRSA; Na(+)/H(+) exchanger 6; NHE-6; NHE6; OTTHUMP00000024089; OTTHUMP00000024090; RGD1563582; RP11-274K13.1; RP23-105E2.4; SL9A6_HUMAN; SLC9A6; Sodium/hydrogen exchanger 6; Solute carrier family 9 (sodium/hydrogen exchanger); isoform 6; Solute carrier family 9 (sodium/hydrogen exchanger); member 6; Solute carrier family 9 member 6; solute carrier family 9; subfamily A (NHE6; cation proton antiporter 6); member 6

Target Background

This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, Christianson type. Alternate splicing results in multiple transcript variants.