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The antibody against SOX4 was raised in rabbit using the Recombinant Human Transcription factor SOX-4 protein (1-60AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against SOX4 was raised in rabbit using the Recombinant Human Transcription factor SOX-4 protein (1-60AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human brain tissue using SOX4 Antibody at dilution of 1:100
Western Blot_x000D_ | Positive WB detected in: Hela whole cell lysate, 293 whole cell lysate, HepG2 whole cell lysate_x000D_ | All lanes: SOX4 antibody at 1:2000_x000D_ | Secondary_x000D_ | Goat polyclonal to rabbit IgG at 1/50000 dilution_x000D_ | Predicted band size: 48 kDa_x000D_ | Observed band size: 48 kDa2
| Cat.No | ADC-12388A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SOX4 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Transcription factor SOX-4 protein (1-60AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q06945 |
Uniprot Id
Q06945
Target Species
Human
Target Name
SOX4
Target Full Name
Transcription factor SOX-4
Target Function
Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Testis, brain, and heart.
Target Synonyms
CSS10; EVI16; SOX4
Target Background
This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.
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