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The antibody against SPG20 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human SPG20 (NP_055902.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against SPG20 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human SPG20 (NP_055902.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-06997A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPG20 |
| Target Synonyms | SPG20; TAHCCP1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse heart, Rat brain, 293T, K-562, Mouse brain, Mouse liver, Rat lung, Rat spleen | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-350 of human SPG20 (NP_055902.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8N0X7 | Immunogen Sequence |
Uniprot Id
Q8N0X7
Target Species
Human
Target Name
SPART
Target Full Name
Spartin
Target Function
May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis.
Target Involvement
Spastic paraplegia 20, autosomal recessive (SPG20)
Target Subcellular Location
Cytoplasm. Midbody.
Target Tissue Specificity
Ubiquitously expressed, with highest levels of expression detected in adipose tissue.
Target Synonyms
SPART; KIAA0610; SPG20; TAHCCP1; Spartin; Spastic paraplegia 20 protein; Trans-activated by hepatitis C virus core protein 1
Target Background
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome).
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