Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
The antibody against SPPL3 was raised in rabbit using the Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against SPPL3 was raised in rabbit using the Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
$299.00
Western BlotPositive WB detected in: Hela whole cell lysate, U87 whole cell lysate, SY5Y whole cell lysate, A549 whole cell lysate, HL-60 whole cell lysate, 293T whole cell lysate, K562 whole cell lysate, mouse brain tissue, rat brain tissueAll lanes: SPPL3 antibody at 1:2000SecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 43, 19 kDaObserved band size: 43 kDa
| Cat.No | ADC-13719A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SPPL3 |
| Form | Liquid | Species Reactivity | Human, Mouse, Rat |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Signal peptide peptidase-like 3 protein (213-263AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8TCT6 |
Uniprot Id
Q8TCT6
Target Species
Human
Target Name
SPPL3
Target Full Name
Signal peptide peptidase-like 3
Target Function
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries. Acts like a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifiying glycosidase and glycosyltransferase enzymes such as MGAT5, B4GAT1 and B4GALT1. Catalyzes the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase (PC)-mediated cleavage proteolysis. May also have the ability to serve as a shedding protease for subsequent intramembrane proteolysis by SPPL2A and SPPL2B of the envelope glycoprotein gp130. Plays a role in the regulation of cellular glycosylation processes. Required to link T-cell antigen receptor (TCR) and calcineurin-NFAT signaling cascades in lymphocytes by promoting the association of STIM1 and ORAI1 during store-operated calcium entry (SOCE) in a protease-independent manner.
Target Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus. Membrane; Multi-pass membrane protein; Lumenal side.
Target Protein Families
Peptidase A22B family
Target Tissue Specificity
Widely expressed. Expressed in the brain.
Target Synonyms
SPPL3; IMP2; PSL4; Signal peptide peptidase-like 3; SPP-like 3; EC 3.4.23.-; Intramembrane protease 2; IMP-2; Presenilin homologous protein 1; PSH1; Presenilin-like protein 4
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
