Rabbit anti-Human SSX2 Polyclonal Antibody

Uniprot Id

Q16385

Target Species

Human

Target Name

SSX2

Target Full Name

Protein SSX2

Target Function

Could act as a modulator of transcription.

Target Involvement

A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

Target Subcellular Location

Nucleus.

Target Protein Families

SSX family

Target Tissue Specificity

Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

Cancer/testis antigen 5.2; Cancer/testis antigen family 5, member 2a; Cancer/testis antigen family 5, member 2b; CT5.2; CT5.2A; CT5.2b; HD21; hom mel 40; HOM-MEL-40; MGC119055; MGC15364; MGC3884; Protein SSX2; RP11-552J9.2; sarcoma, synovial, X-chromosome related 2; SSx; SSX2; SSX2-SYT fusion gene, included; SSX2_HUMAN; SSX2B; Synovial sarcoma; synovial sarcoma X breakpoint 2; Synovial sarcoma, X breakpoint 2B; Tumor antigen HOM-MEL-40; X breakpoint 2

Target Background

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. This gene, and also the SSX1 and SSX4 family members, have been involved in t(X;18)(p11.2;q11.2) translocations that are characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. This gene also has an identical duplicate, GeneID: 727837, located about 45 kb downstream in the opposite orientation on chromosome X.