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The antibody against ST5 was raised in rabbit using the Recombinant Human Suppression of tumorigenicity 5 protein (3-280AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against ST5 was raised in rabbit using the Recombinant Human Suppression of tumorigenicity 5 protein (3-280AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
$299.00
| Cat.No | ADC-01596A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ST5 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Suppression of tumorigenicity 5 protein (3-280AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P78524 |
Uniprot Id
P78524
Target Species
Human
Target Name
DENND2B
Target Full Name
DENN domain-containing protein 2B
Target Function
May be involved in cytoskeletal organization and tumorogenicity. Seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Plays a role in EGFR trafficking from recycling endosomes back to the cell membrane.; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form.; May block ERK2 activation stimulated by ABL1 (Probable). May alter cell morphology and cell growth (Probable).
Target Subcellular Location
[Isoform 1]: Cytoplasm, cell cortex. Cell membrane. Recycling endosome.
Target Tissue Specificity
Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level). Isoform 3 is expressed in primary cell or weakly
Target Synonyms
DENND2B; DENN domain containing protein 2B; DENN domain-containing protein 2B; DENN/MADD domain containing 2B ; HeLa tumor suppression 1; HTS1; p126; ST 5; ST5; ST5_HUMAN; Suppression of tumorigenicity 5; Suppression of tumorigenicity 5 protein
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