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The antibody against SYNE4 was raised in rabbit using the Recombinant Human Nesprin-4 protein (1-242AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against SYNE4 was raised in rabbit using the Recombinant Human Nesprin-4 protein (1-242AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-18734A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SYNE4 |
| Target Synonyms | SYNE4 antibody; C19orf46 antibody; Nesprin-4 antibody; KASH domain-containing protein 4 antibody; KASH4 antibody; Nuclear envelope spectrin repeat protein 4 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Nesprin-4 protein (1-242AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N205 |
Uniprot Id
Q8N205
Target Species
Human
Target Name
SYNE4
Target Full Name
Nesprin-4
Target Function
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus.
Target Involvement
Deafness, autosomal recessive, 76 (DFNB76)
Target Subcellular Location
Nucleus outer membrane; Single-pass type IV membrane protein.
Target Protein Families
Nesprin family
Target Synonyms
SYNE4; C19orf46; Nesprin-4; KASH domain-containing protein 4; KASH4; Nuclear envelope spectrin repeat protein 4
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