Rabbit anti-Human TAF11 Polyclonal Antibody

Uniprot Id

Q15544

Target Species

Human

Target Name

TAF11

Target Full Name

Transcription initiation factor TFIID subunit 11

Target Function

Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively).

Target Subcellular Location

Nucleus.

Target Protein Families

TAF11 family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

MGC:15243; p30 beta ; PRO2134 ; TAF ; TAF(II)28; TAF11; TAF11 RNA polymerase II TATA box binding protein (TBP) associated factor 28 kD; TAF11_HUMAN; TAF2I ; TAFII 28 ; TAFII-28; TAFII28; TFIID subunit p30 beta ; TFIID subunit p30-beta; Transcription initiation factor TFIID 28 kDa subunit; Transcription initiation factor TFIID subunit 11

Target Background

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene.