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The antibody against TAL1 was raised in rabbit using the Synthesized non-phosphopeptide derived from Human TAL-1 around the phosphorylation site of serine 122 (Q-L-S(p)-P-P). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
The antibody against TAL1 was raised in rabbit using the Synthesized non-phosphopeptide derived from Human TAL-1 around the phosphorylation site of serine 122 (Q-L-S(p)-P-P). as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB.
$297.00
Western blot analysis of extracts from Jurkat cells, treated with PMA (125ng/ml, 30mins), using TAL-1 (Ab-122) antibody.
| Cat.No | ADC-42489A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TAL1 |
| Form | Liquid | Species Reactivity | Human, Mouse |
| Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) | Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Synthesized non-phosphopeptide derived from Human TAL-1 around the phosphorylation site of serine 122 (Q-L-S(p)-P-P). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P17542 |
Uniprot Id
P17542
Target Species
Human
Target Name
TAL1
Target Full Name
T-cell acute lymphocytic leukemia protein 1
Target Function
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
Target Involvement
A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.
Target Subcellular Location
Nucleus.
Target Tissue Specificity
Leukemic stem cell.
Target Synonyms
bHLHa17; Class A basic helix-loop-helix protein 17; OTTHUMP00000009563; OTTHUMP00000009564; SCL; STEM CELL LEUKEMIA HEMATOPOIETIC TRANSCRIPTION FACTOR; Stem cell protein; T cell acute lymphocytic leukemia 1; T cell acute lymphocytic leukemia 1 protein ; T cell acute lymphocytic leukemia 1 protein; T cell leukemia/lymphoma 5 protein; T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; Tal 1; Tal 1 product; TAL 1 protein; TAL bHLH transcription factor 1 erythroid differentiation factor; TAL-1; tal1; TAL1_HUMAN; TCL 5; TCL5
Target Background
Enables several functions, including DNA-binding transcription factor activity; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including myeloid cell differentiation; positive regulation of cellular component organization; and positive regulation of erythrocyte differentiation. Located in chromatin and nucleoplasm. Part of transcription regulator complex. Implicated in acute lymphoblastic leukemia.
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