Rabbit anti-Human TESC Polyclonal Antibody

The antibody against TESC was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 135-214 of human TESC (NP_060369.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01129A

Number

Cat.No	ADA-01129A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	TESC
Target Synonyms	TSC; CHP3; TESC	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, 293T, U-87MG	Application	ELISA, WB

Cat.No

ADA-01129A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

TESC

Target Synonyms

TSC; CHP3; TESC

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, 293T, U-87MG

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 135-214 of human TESC (NP_060369.3).	Target Species	Human
Immunogen Sequence	YRNVVEELLSGNPHIEKESARSIADGAMMEAASVCMGQMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH	Uniprot ID	Q96BS2

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 135-214 of human TESC (NP_060369.3).

Target Species

Human

Immunogen Sequence

YRNVVEELLSGNPHIEKESARSIADGAMMEAASVCMGQMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH

Uniprot ID

Q96BS2

Background Information

Uniprot Id

Q96BS2
Target Species

Human
Target Name

TESC
Target Full Name

Calcineurin B homologous protein 3
Target Function

Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
Target Subcellular Location

Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane.
Target Protein Families

Calcineurin regulatory subunit family, CHP subfamily
Target Tissue Specificity

Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
Target Research Area

Signal Transduction
Target Synonyms

TESC; CHP3Calcineurin B homologous protein 3; Tescalcin; TSC
Target Background

Enables calcium ion binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of macromolecule metabolic process; and positive regulation of myeloid cell differentiation. Located in several cellular components, including cytosol; lamellipodium; and nucleoplasm.

Rabbit anti-Human TESC Polyclonal Antibody

Specifications

Immunogen Information

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