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The antibody against TIMP4 was raised in rabbit using the Recombinant Human Metalloproteinase inhibitor 4 protein (31-224AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
The antibody against TIMP4 was raised in rabbit using the Recombinant Human Metalloproteinase inhibitor 4 protein (31-224AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC, IF.
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Immunohistochemistry of paraffin-embedded human colon cancer using TIMP4 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human kidney tissue using TIMP4 Antibody at dilution of 1:1002
Immunofluorescent analysis of Hela cells using TIMP4 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)3
| Cat.No | ADC-46196A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TIMP4 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Metalloproteinase inhibitor 4 protein (31-224AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q99727 |
Uniprot Id
Q99727
Target Species
Human
Target Name
TIMP4
Target Full Name
Metalloproteinase inhibitor 4
Target Function
Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
Target Subcellular Location
Secreted.
Target Protein Families
Protease inhibitor I35 (TIMP) family
Target Tissue Specificity
Abundant in heart and present at low levels in many other tissues.
Target Research Area
Cancer, Cardiovascular
Target Synonyms
Metalloproteinase inhibitor 4; TIMP 4; TIMP metallopeptidase inhibitor 4; TIMP-4; Timp4; TIMP4_HUMAN; Tissue inhibitor of metalloproteinase 4; Tissue inhibitor of metalloproteinases 4
Target Background
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.
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