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The antibody against TMEM59 was raised in rabbit using the Recombinant Human Transmembrane protein 59 protein (59-201AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against TMEM59 was raised in rabbit using the Recombinant Human Transmembrane protein 59 protein (59-201AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
$299.00
| Cat.No | ADC-09648A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TMEM59 |
| Target Synonyms | TMEM59; C1orf8; HSPC001; UNQ169/PRO195; Transmembrane protein 59; Liver membrane-bound protein | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Transmembrane protein 59 protein (59-201AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9BXS4 |
Uniprot Id
Q9BXS4
Target Species
Human
Target Name
TMEM59
Target Full Name
Transmembrane protein 59
Target Function
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
Target Subcellular Location
Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein.
Target Protein Families
TMEM59 family
Target Synonyms
TMEM59; C1orf8; HSPC001; UNQ169/PRO195; Transmembrane protein 59; Liver membrane-bound protein
Target Background
This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants.
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