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The antibody against TMTC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 615-914 of human TMTC3 (NP_861448.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TMTC3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 615-914 of human TMTC3 (NP_861448.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05550A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TMTC3 |
| Target Synonyms | LIS8; SMILE; TMTC3 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, HT-29 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 615-914 of human TMTC3 (NP_861448.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q6ZXV5 | Immunogen Sequence |
Uniprot Id
Q6ZXV5
Target Species
Human
Target Name
TMTC3
Target Full Name
Protein O-mannosyl-transferase TMTC3
Target Function
Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases dedicated primarily to the cadherin superfamily, each member seems to have a distinct role in decorating the cadherin domains with O-linked mannose glycans at specific regions. Also acts as O-mannosyl-transferase on other proteins such as PDIA3. Involved in the positive regulation of proteasomal protein degradation in the endoplasmic reticulum (ER), and the control of ER stress response.
Target Involvement
Lissencephaly 8 (LIS8)
Target Subcellular Location
Membrane; Multi-pass membrane protein. Endoplasmic reticulum.
Target Protein Families
TMTC family
Target Synonyms
TMTC3; Protein O-mannosyl-transferase TMTC3; EC 2.4.1.109; Protein SMILE; Transmembrane and TPR repeat-containing protein 3
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