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The antibody against TPH2 was raised in rabbit using the Peptide sequence around phosphorylation site of Serine 19(G-F-S(p)-L-D) derived from Human TPH2. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, WB.
The antibody against TPH2 was raised in rabbit using the Peptide sequence around phosphorylation site of Serine 19(G-F-S(p)-L-D) derived from Human TPH2. as the immunogen. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi This antibody has been validated on ELISA, WB.
$360.00
| Cat.No | ADC-42659A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TPH2 |
| Target Synonyms | TPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Peptide sequence around phosphorylation site of Serine 19(G-F-S(p)-L-D) derived from Human TPH2. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8IWU9 |
Uniprot Id
Q8IWU9
Target Species
Human
Target Name
TPH2
Target Full Name
Tryptophan 5-hydroxylase 2
Target Involvement
Major depressive disorder (MDD); Attention deficit-hyperactivity disorder 7 (ADHD7)
Target Protein Families
Biopterin-dependent aromatic amino acid hydroxylase family
Target Tissue Specificity
Brain specific.
Target Research Area
Neuroscience
Target Synonyms
TPH2; NTPH; Tryptophan 5-hydroxylase 2; Neuronal tryptophan hydroxylase; Tryptophan 5-monooxygenase 2
Target Background
This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.
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