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The antibody against TRAF3IP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 386-625 of human TRAF3IP1 (NP_001132962.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against TRAF3IP1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 386-625 of human TRAF3IP1 (NP_001132962.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-01066A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRAF3IP1 |
| Target Synonyms | IFT54; MIPT3; SLSN9; FAP116; MIP-T3; CFAP116; TRAF3IP1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Mouse kidney, 293T, A-549, Mouse brain, Mouse lung, Mouse testis, Rat kidney, Rat testis | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 386-625 of human TRAF3IP1 (NP_001132962.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q8TDR0 | Immunogen Sequence |
Uniprot Id
Q8TDR0
Target Species
Human
Target Name
TRAF3IP1
Target Full Name
TRAF3-interacting protein 1
Target Function
Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis.
Target Involvement
Senior-Loken syndrome 9 (SLSN9)
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
Target Protein Families
TRAF3IP1 family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
Interleukin 13 receptor alpha 1 binding protein 1; Interleukin-13 receptor alpha 1-binding protein 1; Microtubule interacting protein that associates with TRAF3; Microtubule-interacting protein associated with TRAF3; MIP T3; MIP-T3; MIPT3; MIPT3_HUMAN; TNF receptor associated factor 3 interacting protein 1; TRAF3-interacting protein 1; Traf3ip1
Target Background
The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9.
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