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The antibody against TRAF3IP1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human MIP-T3. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, IF, ELISA.
The antibody against TRAF3IP1 was raised in rabbit using the Synthesized peptide derived from the Internal region of Human MIP-T3. as the immunogen. This antibody exists as a non-conjugated isotype IgG. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on IHC, IF, ELISA.
$167.00
| Cat.No | ADC-35676A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TRAF3IP1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.5% BSA and 0.02% sodium azide., Liquid in PBS containing 50% glycerol |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Conjugate | Non-conjugated |
| Application | ELISA, IF, IHC | Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from the Internal region of Human MIP-T3. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8TDR0 |
Uniprot Id
Q8TDR0
Target Species
Human
Target Name
TRAF3IP1
Target Full Name
TRAF3-interacting protein 1
Target Function
Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. Involved in kidney development and epithelial morphogenesis. Involved in the regulation of microtubule cytoskeleton organization. Is a negative regulator of microtubule stability, acting through the control of MAP4 levels. Involved in ciliogenesis.
Target Involvement
Senior-Loken syndrome 9 (SLSN9)
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, cilium basal body.
Target Protein Families
TRAF3IP1 family
Target Tissue Specificity
Ubiquitous.
Target Synonyms
Interleukin 13 receptor alpha 1 binding protein 1; Interleukin-13 receptor alpha 1-binding protein 1; Microtubule interacting protein that associates with TRAF3; Microtubule-interacting protein associated with TRAF3; MIP T3; MIP-T3; MIPT3; MIPT3_HUMAN; TNF receptor associated factor 3 interacting protein 1; TRAF3-interacting protein 1; Traf3ip1
Target Background
The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9.
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