Rabbit anti-Human TRIM39 Polyclonal Antibody

Uniprot Id

Q9HCM9

Target Species

Human

Target Name

TRIM39

Target Full Name

E3 ubiquitin-protein ligase TRIM39

Target Function

E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation.; Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation. Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner.

Target Subcellular Location

[Isoform 1]: Cytoplasm, cytosol. Mitochondrion. Nucleus.; [Isoform 2]: Nucleus.

Target Protein Families

TRIM/RBCC family

Target Tissue Specificity

Ubiquitous; highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis.

Target Synonyms

HGNC:10065; MGC32984; RING finger protein 23; RNF23; Testis abundant finger protein; Testis-abundant finger protein; TFP; TFP RING FINGER PROTEIN 23; TRI39_HUMAN; Trim39; TRIM39B; Tripartite motif containing 39; Tripartite motif-containing protein 39

Target Background

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The function of this protein has not been identified. This gene lies within the major histocompatibility complex class I region on chromosome 6. Alternate splicing results in two transcript variants encoding different isoforms.