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The antibody against TSHR was raised in rabbit using the Recombinant Human Thyrotropin receptor protein (21-413AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against TSHR was raised in rabbit using the Recombinant Human Thyrotropin receptor protein (21-413AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
$299.00
Immunofluorescent analysis of Hela cells using TSHR Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-50569A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TSHR |
| Target Synonyms | TSHR; LGR3; Thyrotropin receptor; Thyroid-stimulating hormone receptor; TSH-R | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.1mol/L NaCl, 15mmol/L NaN3, PH7.2 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Thyrotropin receptor protein (21-413AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P16473 |
Uniprot Id
P16473
Target Species
Human
Target Name
TSHR
Target Full Name
Thyrotropin receptor
Target Function
Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism.
Target Involvement
Hypothyroidism, congenital, non-goitrous, 1 (CHNG1); Familial gestational hyperthyroidism (HTFG); Hyperthyroidism, non-autoimmune (HTNA)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.
Target Protein Families
G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
Target Tissue Specificity
Expressed in thyroide cells (at protein level). Expressed in the thyroid.
Target Synonyms
LGR3; CHNG1; hTSHR-I; TSHR
Target Background
The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.
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