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The antibody against VWF was raised in rabbit using the Recombinant Human von Willebrand factor protein (1-273AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against VWF was raised in rabbit using the Recombinant Human von Willebrand factor protein (1-273AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human brain tissue using VWF Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human tonsil tissue using VWF Antibody at dilution of 1:1002
| Cat.No | ADC-49513A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | VWF |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | Recombinant Human von Willebrand factor protein (1-273AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P04275 |
Uniprot Id
P04275
Target Species
Human
Target Name
VWF
Target Full Name
von Willebrand factor
Target Function
Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
Target Involvement
von Willebrand disease 1 (VWD1); von Willebrand disease 2 (VWD2); von Willebrand disease 3 (VWD3)
Target Subcellular Location
Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules.
Target Tissue Specificity
Plasma.
Target Synonyms
VWD; F8VWF; von Willebrand factor (VWF)
Target Background
This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22.
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