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The antibody against ZC3H8 was raised in rabbit using the Synthesized peptide derived from internal of Human ZC3H8. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
The antibody against ZC3H8 was raised in rabbit using the Synthesized peptide derived from internal of Human ZC3H8. as the immunogen. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This antibody has been validated on ELISA, WB, IHC.
$297.00
Western blot analysis of extracts from HepG2 cells, using ZC3H8 antibody.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using ZC3H8 antibody.2
| Cat.No | ADC-40809A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZC3H8 |
| Target Synonyms | Fliz1 antibody; Zc3h8 antibody; ZC3H8_HUMAN antibody; Zinc finger CCCH domain containing protein 8 antibody; Zinc finger CCCH domain-containing protein 8 antibody | Form | Liquid |
| Species Reactivity | Human | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) |
| Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Synthesized peptide derived from internal of Human ZC3H8. | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q8N5P1 |
Uniprot Id
Q8N5P1
Target Species
Human
Target Name
ZC3H8
Target Full Name
Zinc finger CCCH domain-containing protein 8
Target Function
Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
Target Subcellular Location
Nucleus. Note=Colocalizes with coilin in subnuclear cajal and histone locus bodies. Translocates in the LEC complex to cajal and histone locus bodies at snRNA genes in a ICE1-dependent manner. Associates to transcriptionally active chromatin at snRNA genes.
Target Synonyms
Fliz1; Zc3h8; ZC3H8_HUMAN; Zinc finger CCCH domain containing protein 8; Zinc finger CCCH domain-containing protein 8
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