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The antibody against Sry was raised in rabbit using the Recombinant Mouse Sex-determining region Y protein (1-143AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against Sry was raised in rabbit using the Recombinant Mouse Sex-determining region Y protein (1-143AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-50641A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SRY |
| Target Synonyms | Sry antibody; Tdf antibody; Tdy antibody; Sex-determining region Y protein antibody; Testis-determining factor antibody | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Mouse Sex-determining region Y protein (1-143AA) | Target Species | Mus musculus (Mouse) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q05738 |
Uniprot Id
Q05738
Target Species
Mouse
Target Name
SRY
Target Full Name
Sex-determining region Y protein
Target Function
Transcriptional regulator that controls a genetic switch in male development. It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells. Involved in different aspects of gene regulation including promoter activation or repression. Binds to the DNA consensus sequence 5'-Constitutes the major isoform, which is necessary and sufficient for initiating male sex determination.; Constitutes a minor isoform, which is unstable due to the presence of a degron at the C-terminus that promotes its degradation. Not necessary and sufficient for initiating male sex determination.
Target Subcellular Location
Nucleus speckle. Cytoplasm. Nucleus.
Target Protein Families
SRY family
Target Tissue Specificity
Expressed in gonadal somatic pre-Sertoli cells. Expressed in the substantia nigra of the brain (at protein level). Expressed in diencephalon, cortex, the substantia nigra of the midbrain and the medial mammillary bodies of the hypothalamus of male, but no
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