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The antibody against E3L was raised in rabbit using the Recombinant Vaccinia virus Protein E3 (E3L) (1-190AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein A/G purified. This antibody has been validated on ELISA, WB.
The antibody against E3L was raised in rabbit using the Recombinant Vaccinia virus Protein E3 (E3L) (1-190AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein A/G purified. This antibody has been validated on ELISA, WB.
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Western Blot | Positive WB detected in Recombinant protein | All lanes: E3L antibody at 1:2000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 28.5 kDa | Observed band size: 29 kDa
| Cat.No | ADC-01735A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | E3L |
| Target Synonyms | E3L antibody; Protein E3 antibody; p25 antibody | Form | Liquid |
| Species Reactivity | Vaccinia virus | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Protein A/G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Vaccinia virus Protein E3 (E3L) (1-190AA) | Target Species | Vaccinia virus (strain Copenhagen) (VACV) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P21081 |
Uniprot Id
P21081
Target Species
Vaccinia virus
Target Name
E3L
Target Function
Plays a role in the inhibition of multiple cellular antiviral responses activated by dsRNA, such as inhibition of PKR activation, apoptosis, and IFN-mediated antiviral activities. Blocks also the phosphorylation and subsequent activation of IRF3 and IRF7 kinases that are required for interferon-alpha gene expression. Inhibits NF-kappa-B activation and the ubiquitin-like protein ISG15, which is an early antiviral protein. The binding with host ISG15 subsequently blocks host ISGylation. Inhibits ZBP1-dependent necroptosis via interaction with host ZBP1.
Target Protein Families
Poxviridae E3 protein family
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