Mitochondrial Inner Membrane Protease Atp23 Homolog (ATP23) Reagents

Mitochondrial inner membrane protease ATP23 homolog

ATP23; KUB3; XRCC6BP1Mitochondrial inner membrane protease ATP23 homolog; EC 3.4.24.-; Ku70-binding protein 3; XRCC6-binding protein 1

The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene.