B1 Bradykinin Receptor (BDKRB1) Reagents

B1 bradykinin receptor

This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.

Cell membrane; Multi-pass membrane protein.

G-protein coupled receptor 1 family, Bradykinin receptor subfamily, BDKRB1 sub-subfamily

BDKRB1; BRADYB1; B1 bradykinin receptor; B1R; BK-1 receptor

Bradykinin, a 9 aa peptide, is generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The protein encoded by this gene belongs to the G-protein coupled receptor 1 family. Two types of G-protein coupled receptors have been found which bind bradykinin and mediate responses to these pathophysiologic conditions. The protein encoded by this gene is one of these receptors and is synthesized de novo following tissue injury. Receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.