Electron Transfer Flavoprotein Subunit Beta (ETFB) Reagents

Electron transfer flavoprotein subunit beta

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism. ETFB binds an AMP molecule that probably has a purely structural role.

Glutaric aciduria 2B (GA2B)

Mitochondrion matrix.

ETF beta-subunit/FixA family

Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.

Beta ETF; Beta-ETF; Electron transfer flavoprotein beta polypeptide ; Electron transfer flavoprotein beta subunit ; Electron transfer flavoprotein subunit beta; Electron transferring flavoprotein beta polypeptide ; etfB; ETFB_HUMAN; FP585; MADD

This gene encodes electron-transfer-flavoprotein, beta polypeptide, which shuttles electrons between primary flavoprotein dehydrogenases involved in mitochondrial fatty acid and amino acid catabolism and the membrane-bound electron transfer flavoprotein ubiquinone oxidoreductase. The gene deficiencies have been implicated in type II glutaricaciduria. Alternatively spliced transcript variants have been found for this gene.