Btb/Poz Domain-Containing Adapter For Cul3-Mediated Rhoa Degradation Protein 3 (KCTD10) Reagents

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(BACURD3) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.

Nucleus.

BACURD family

KCTD10; ULR061; MSTP028BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3; hBACURD3; BTB/POZ domain-containing protein KCTD10; Potassium channel tetramerization domain-containing protein 10

The protein encoded by this gene binds proliferating cell nuclear antigen (PCNA) and may be involved in DNA synthesis and cell proliferation. In addition, the encoded protein may be a tumor suppressor. Several protein-coding and non-protein coding transcript variants have been found for this gene.