Proprotein Convertase Subtilisin/Kexin Type 4 (PCSK4) Reagents

Proprotein convertase subtilisin/kexin type 4

Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida. Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2. May also participate in folliculogenesis in the ovaries.

Membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane.

Peptidase S8 family, Furin subfamily

Placenta.

PCSK4; PC4; UNQ2757/PRO6496; Proprotein convertase subtilisin/kexin type 4; Proprotein convertase 4; PC4