Phosphate-Regulating Neutral Endopeptidase Phex (PHEX) Reagents

Phosphate-regulating neutral endopeptidase PHEX

Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity. Cleaves ASARM peptides between Ser and Glu or Asp residues. Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation.

Hypophosphatemic rickets, X-linked dominant (XLHR)

Cell membrane; Single-pass type II membrane protein.

Peptidase M13 family

Specifically expressed in ovary. Expressed at low levels in kidney.

PHEX; PEX; Phosphate-regulating neutral endopeptidase PHEX; Metalloendopeptidase homolog PEX; Vitamin D-resistant hypophosphatemic rickets protein; X-linked hypophosphatemia protein; HYP