O-Phosphoseryl-Trna(Sec) Selenium Transferase (SEPSECS) Reagents

O-phosphoseryl-tRNA(Sec) selenium transferase

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

Pontocerebellar hypoplasia 2D (PCH2D)

Cytoplasm.

SepSecS family

Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells.

Epigenetics and Nuclear Signaling, Metabolism

DKFZp434B1417; Liver pancreas antigen; Liver-pancreas antigen; LP; MGC161491; O phosphoseryl tRNA(Sec) selenium transferase; O-phosphoseryl-tRNA(Sec) selenium transferase; Sec synthase; Selenocysteine synthase; Selenocysteinyl tRNA(Sec) synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep (O phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase; Sep tRNA:Sec tRNA synthase; Sep-tRNA:Sec-tRNA synthase; SepSecS; SLA; SLA p35; SLA-p35; SLA/LP; SLA/LP autoantigen; Soluble liver antigen; Soluble liver antigen/liver pancreas antigen; Soluble Liver/Pancreas Antigen; SPCS_HUMAN; tRNA(Ser/Sec) associated antigenic protein; tRNA(Ser/Sec)-associated antigenic protein; TRNP48; UGA suppressor tRNA associated protein; UGA suppressor tRNA-associated protein

The amino acid selenocysteine is the only amino acid that does not have its own tRNA synthetase. Instead, this amino acid is synthesized on its cognate tRNA in a three step process. The protein encoded by this gene catalyzes the third step in the process, the conversion of O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).