Transmembrane Protein 119 (TMEM119) Reagents

Transmembrane protein 119

Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts. May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Upregulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation.

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Endoplasmic reticulum membrane.

Expressed in brain microglia (at protein level). Elevated expression levels seen in the brain of patients with Alzheimer disease. Expressed by osteoblast-like cells in bone tissues and follicular dendritic cells in lymphoid tissues.

Others

TMEM119; PSEC0199; UNQ731/PRO1415; Transmembrane protein 119; Osteoblast induction factor; OBIF