Rabbit anti-Human SAA1 Polyclonal Antibody

Uniprot Id

P0DJI8

Target Species

Human

Target Name

SAA1

Target Full Name

Serum amyloid A-1 protein

Target Function

Major acute phase protein.

Target Involvement

Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.

Target Subcellular Location

Secreted.

Target Protein Families

SAA family

Target Tissue Specificity

Expressed by the liver; secreted in plasma (at protein level).

Target Synonyms

SAA; PIG4; SAA2; TP53I4; SAA1

Target Background

This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Finally, antimicrobial activity against S. aureus and E. coli resides in the N-terminal portion of the mature protein. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.