Rabbit anti-Human PLGF Polyclonal Antibody

The antibody against PLGF was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 19-170 of human PLGF (NP_002623.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-11894A

Number

Cat.No	ADA-11894A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	PLGF
Target Synonyms	PGFL; PIGF; PLGF; PlGF-2; D12S1900; SHGC-10760	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	Rat brain, 293T, HT-29, MCF7, Mouse brain, Mouse liver	Application	ELISA, WB

Cat.No

ADA-11894A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

PLGF

Target Synonyms

PGFL; PIGF; PLGF; PlGF-2; D12S1900; SHGC-10760

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

Rat brain, 293T, HT-29, MCF7, Mouse brain, Mouse liver

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 19-170 of human PLGF (NP_002623.2).	Target Species	Human
Immunogen Sequence	LPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRPLREKMKPERRRPKGRGKRRREKQRPTDCHLCGDAVPRR	Uniprot ID	P49763

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 19-170 of human PLGF (NP_002623.2).

Target Species

Human

Immunogen Sequence

LPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRPLREKMKPERRRPKGRGKRRREKQRPTDCHLCGDAVPRR

Uniprot ID

P49763

Background Information

Uniprot Id

P49763
Target Species

Human
Target Name

PGF
Target Full Name

Placenta growth factor
Target Function

Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
Target Subcellular Location

Secreted. Note=The three isoforms are secreted but PlGF-2 appears to remain cell attached unless released by heparin.
Target Protein Families

PDGF/VEGF growth factor family
Target Tissue Specificity

While the three isoforms are present in most placental tissues, PlGF-2 is specific to early (8 week) placenta and only PlGF-1 is found in the colon and mammary carcinomas.
Target Research Area

Cardiovascular
Target Synonyms

D12S1900; Pgf; PGFL; PIGF; Placenta growth factor; Placental growth factor; Placental growth factor; vascular endothelial growth factor related protein; PlGF 2; PlGF; PLGF_HUMAN; PlGF2; SHGC 10760
Target Background

Enables growth factor activity. Involved in positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in several diseases, including brain ischemia; diabetic neuropathy; glioblastoma; myocardial infarction; and pancreatic endocrine carcinoma. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); epilepsy (multiple); limited scleroderma; and pancreatic endocrine carcinoma.

Rabbit anti-Human PLGF Polyclonal Antibody

Specifications

Immunogen Information

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