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The antibody against BACH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human BACH1 (NP_996749.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ELISA.
The antibody against BACH1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human BACH1 (NP_996749.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ELISA.
Western blot analysis of lysates from HEL cells, using BACH1 Rabbit pAb at 1:2000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 60s.
| Cat.No | ADA-12567A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | BACH1 |
| Target Synonyms | BACH-1; BTBD24; BACH1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HEL, K-562 | Application | ELISA, WB, IP |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-320 of human BACH1 (NP_996749.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O14867 | Immunogen Sequence |
Uniprot Id
O14867
Target Species
Human
Target Name
BACH1
Target Full Name
Transcription regulator protein BACH1
Target Function
Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK. Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway.
Target Subcellular Location
Nucleus.
Target Protein Families
BZIP family, CNC subfamily
Target Synonyms
BACH 1; BACH 1.3; Bach1; BACH1_HUMAN; Basic leucine zipper transcription factor 1; basic region leucine zipper transcriptional regulator BACH1; BTB and CNC homolog 1; BTB and CNC homology 1; BTB and CNC homology 1; basic leucine zipper transcription factor 1; HA2303; OTTHUMP00000096563; OTTHUMP00000096564; Transcription regulator protein BACH1
Target Background
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
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