Rabbit anti-Human TLE1 Monoclonal Antibody

The antibody against TLE1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 150-250 of human TLE1 (Q04724) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, ELISA.

ADA-13798A

Number

Cat.No	ADA-13798A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	TLE1
Target Synonyms	ESG; ESG1; GRG1; TLE-1; TLE1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HepG2, Mouse brain, Mouse lung, Rat liver, Rat lung, U-87MG	Application	ELISA, WB, IHC-P

Cat.No

ADA-13798A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

TLE1

Target Synonyms

ESG; ESG1; GRG1; TLE-1; TLE1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HepG2, Mouse brain, Mouse lung, Rat liver, Rat lung, U-87MG

Application

ELISA, WB, IHC-P

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TLE1 (Q04724).	Target Species	Human
Immunogen Sequence	LQPPGIPPLGGSAGLLALSSALSGQSHLAIKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSDGDKSDDNLVV	Uniprot ID	Q04724

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TLE1 (Q04724).

Target Species

Human

Immunogen Sequence

LQPPGIPPLGGSAGLLALSSALSGQSHLAIKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSDGDKSDDNLVV

Uniprot ID

Q04724

Background Information

Uniprot Id

Q04724
Target Species

Human
Target Name

TLE1
Target Full Name

Transducin-like enhancer protein 1
Target Function

Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Target Subcellular Location

Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
Target Protein Families

WD repeat Groucho/TLE family
Target Tissue Specificity

In all tissues examined, mostly in brain, liver and muscle.
Target Synonyms

ESG; ESG1; GRG1; TLE-1; TLE1
Target Background

Enables identical protein binding activity and transcription corepressor activity. Involved in negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of anoikis; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex.

Rabbit anti-Human TLE1 Monoclonal Antibody

Specifications

Immunogen Information

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