Rabbit anti-Human NEK7 Monoclonal Antibody

The antibody against NEK7 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 203-302 of human NEK7 (Q8TDX7) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-14279A

Number

Cat.No	ADA-14279A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	NEK7
Target Synonyms	NIMA-related kinase 7; NEK7	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	C6, HeLa, NIH/3T3, MCF7, Mouse liver, Mouse lung	Application	ELISA, WB

Cat.No

ADA-14279A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

NEK7

Target Synonyms

NIMA-related kinase 7; NEK7

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

C6, HeLa, NIH/3T3, MCF7, Mouse liver, Mouse lung

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 203-302 of human NEK7 (Q8TDX7).	Target Species	Human
Immunogen Sequence	MSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTASS	Uniprot ID	Q8TDX7

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 203-302 of human NEK7 (Q8TDX7).

Target Species

Human

Immunogen Sequence

MSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNMCINPDPEKRPDVTYVYDVAKRMHACTASS

Uniprot ID

Q8TDX7

Background Information

Uniprot Id

Q8TDX7
Target Species

Human
Target Name

NEK7
Target Full Name

Serine/threonine-protein kinase Nek7
Target Function

Protein kinase which plays an important role in mitotic cell cycle progression. Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis. Phosphorylates RPS6KB1. Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression.
Target Subcellular Location

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Target Protein Families

Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily
Target Tissue Specificity

Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney. No expression seen in small intestine.
Target Synonyms

EC 2.7.11.1; NEK7; NEK7_HUMAN; Never in mitosis A-related kinase 7; Never in mitosis gene a-related kinase 7; NIMA (never in mitosis gene a) related kinase 7; NIMA (never in mitosis gene a)-related expressed kinase 7; NimA related protein kinase 7 ; NIMA-related kinase 7; NimA-related protein kinase 7; Serine/threonine-protein kinase Nek7
Target Background

NIMA-related kinases share high amino acid sequence identity with the gene product of the Aspergillus nidulans 'never in mitosis A' gene, which controls initiation of mitosis.

Rabbit anti-Human NEK7 Monoclonal Antibody

Specifications

Immunogen Information

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